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Stephen I Deutsch Selected Research

Dizocilpine Maleate (Dizocilpine)

5/2014NMDA receptors on the surface of cancer cells: target for chemotherapy?
8/2011Selective mGluR5 antagonism attenuates the stress-induced reduction of MK-801's antiseizure potency in the genetically inbred Balb/c mouse.
10/2010Locomotor activity of the genetically inbred Balb/c mouse strain is suppressed by a socially salient stimulus.
3/2010NMDA NR2B subtype-selective receptor antagonists fail to antagonize electrically-precipitated seizures and elicit popping in mice.
6/2009An epigenetic intervention interacts with genetic strain differences to modulate the stress-induced reduction of flurazepam's antiseizure efficacy in the mouse.
11/2008Expression of NR1, NR2A and NR2B NMDA receptor subunits is not altered in the genetically-inbred Balb/c mouse strain with heightened behavioral sensitivity to MK-801, a noncompetitive NMDA receptor antagonist.
8/2008Sodium butyrate, an epigenetic interventional strategy, attenuates a stress-induced alteration of MK-801's pharmacologic action.
1/2008Phencyclidine and dizocilpine induced behaviors reduced by N-acetylaspartylglutamate peptidase inhibition via metabotropic glutamate receptors.
1/2007Exogenously administered D-serine failed to potentiate the ability of MK-801 to antagonize electrically precipitated seizures in nonhandled control and stressed mice.
8/2004Anabasine, a selective nicotinic acetylcholine receptor agonist, antagonizes MK-801-elicited mouse popping behavior, an animal model of schizophrenia.
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Stephen I Deutsch Research Topics

Disease

25Schizophrenia (Dementia Praecox)
04/2014 - 08/2002
17Autism Spectrum Disorder
01/2020 - 10/2010
11Seizures (Absence Seizure)
08/2011 - 01/2003
8Psychotic Disorders (Schizoaffective Disorder)
04/2014 - 01/2003
4Neurodevelopmental Disorders
01/2021 - 07/2015
4Alzheimer Disease (Alzheimer's Disease)
12/2006 - 09/2002
3Autistic Disorder (Autism)
01/2022 - 05/2010
3Down Syndrome (Down's Syndrome)
10/2015 - 09/2003
2Amyloid Plaque
10/2015 - 09/2003
2Tuberous Sclerosis (Bourneville's Disease)
07/2015 - 01/2014
2Dementia (Dementias)
10/2014 - 09/2003
2Neoplasms (Cancer)
05/2014 - 05/2008
2Fragile X Syndrome (Martin Bell Syndrome)
01/2014 - 10/2011
2Cognitive Dysfunction
08/2013 - 09/2002
2Epilepsy (Aura)
05/2010 - 05/2006
2Huntington Disease (Huntington's Disease)
08/2008 - 03/2008
1Chromosome 15q13.3 Microdeletion Syndrome
01/2020
1Neurofibromatosis 1 (Neurofibromatosis Type I)
01/2014
1Abdominal Pain (Pain, Abdominal)
08/2013
1Headache (Headaches)
08/2013
1Hypersensitivity (Allergy)
10/2010
1Lissencephaly
05/2010
1Hyperammonemia
11/2009
1Brain Diseases (Brain Disorder)
11/2009
1Temporal Lobe Epilepsy
05/2009
1Panic Disorder (Panic Attack)
05/2009
1Marijuana Abuse (Cannabis Abuse)
05/2008
1Dystonia (Limb Dystonia)
05/2008
1Tics (Tic)
05/2008
1Multiple Sclerosis
05/2008
1Neurodegenerative Diseases (Neurodegenerative Disease)
03/2008
1Williams Syndrome (Williams-Beuren Syndrome)
12/2007
1Sarcosinemia
11/2006
1Substance-Related Disorders (Drug Abuse)
05/2006

Drug/Important Bio-Agent (IBA)

23N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
01/2022 - 08/2002
14Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA
01/2020 - 09/2002
13Dizocilpine Maleate (Dizocilpine)IBA
05/2014 - 08/2002
8Phencyclidine (Angel Dust)IBA
11/2008 - 08/2002
7N-Methylaspartate (NMDA)IBA
01/2015 - 08/2002
5Galantamine (Galanthamine)FDA LinkGeneric
08/2013 - 09/2002
4Cholinergic ReceptorsIBA
01/2020 - 09/2002
4Cholinergic Agents (Cholinergics)IBA
01/2020 - 09/2003
4alpha7 Nicotinic Acetylcholine ReceptorIBA
08/2013 - 09/2003
3Acetylcholine (Acetylcholine Chloride)FDA Link
01/2020 - 03/2003
3Biological ProductsIBA
10/2019 - 01/2005
3Peptides (Polypeptides)IBA
10/2015 - 03/2003
3Cycloserine (Seromycin)FDA Link
01/2015 - 07/2013
3Proteins (Proteins, Gene)FDA Link
05/2014 - 09/2003
3Antipsychotic Agents (Antipsychotics)IBA
08/2013 - 09/2002
3Topiramate (Topamax)FDA LinkGeneric
11/2009 - 08/2002
2Sirolimus (Rapamycin)FDA Link
07/2015 - 01/2014
2Glycine (Aminoacetic Acid)FDA LinkGeneric
01/2015 - 11/2008
2TOR Serine-Threonine KinasesIBA
05/2014 - 01/2014
2Cytidine Diphosphate Choline (Citicoline)IBA
08/2013 - 02/2008
2Nicotinic AgonistsIBA
05/2010 - 01/2008
2gamma-Aminobutyric Acid (GABA)IBA
01/2010 - 01/2005
2Sarcosine (Methylglycine)IBA
11/2008 - 11/2006
2PurinesIBA
04/2008 - 01/2005
2GuanineIBA
04/2008 - 01/2005
2Therapeutic UsesIBA
12/2004 - 07/2003
1MetalsIBA
01/2021
1ParvalbuminsIBA
01/2021
1CationsIBA
01/2021
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2020
1GlucocorticoidsIBA
01/2020
1LipidsIBA
10/2015
1VU0410120IBA
08/2015
1Mechanistic Target of Rapamycin Complex 1IBA
07/2015
1LigandsIBA
05/2014
1Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
05/2014
1Paliperidone PalmitateFDA Link
04/2014
1PlacebosIBA
08/2013
1Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA
10/2011
1Complement System Proteins (Complement)IBA
05/2010
1VLDL LipoproteinsIBA
05/2010
1ifenprodilIBA
03/2010
14- (3- (4- (4- fluoro- phenyl)- 3,6- dihydro- 2H- pyridin- 1- yl)- 2- hydroxy- propoxy)- benzamideIBA
03/2010
1Flurazepam (Dalmane)FDA LinkGeneric
11/2009
1Valproic Acid (Depakote)FDA LinkGeneric
11/2009
1Butyric Acid (Butanoic Acid)IBA
06/2009
1Histone Deacetylase InhibitorsIBA
06/2009
1Carbamazepine (Tegretol)FDA LinkGeneric
05/2009
1Histones (Histone)IBA
08/2008
1Nucleosomes (Nucleosome)IBA
08/2008
1DNA (Deoxyribonucleic Acid)IBA
08/2008
1Dronabinol (THC)FDA LinkGeneric
05/2008
1GuanosineIBA
04/2008
1Mutant Proteins (Protein, Mutant)IBA
03/2008
1polyglutamineIBA
03/2008
1Ligand-Gated Ion ChannelsIBA
02/2008
1Glutamate Carboxypeptidase II (N-Acetylaspartylglutamate Peptidase)IBA
01/2008
1ZJ43IBA
01/2008
1CytidineIBA
01/2008
1Serine (L-Serine)FDA Link
01/2007
1tau Proteins (tau Protein)IBA
12/2006
1Glycine Plasma Membrane Transport ProteinsIBA
11/2006
1Hypoxanthine Phosphoribosyltransferase (Hypoxanthine Guanine Phosphoribosyltransferase)IBA
01/2005
1Glutamate Receptors (Glutamate Receptor)IBA
01/2005
1Neurotransmitter Agents (Neurotransmitter)IBA
01/2005

Therapy/Procedure

5Drug Therapy (Chemotherapy)
05/2014 - 03/2003